Low Dose Radiation Therapy for Osteoarthritis

Project in progress. Details to be added later…

Low dose radiation therapy (LDRT) is an effective symptom management option for osteoarthritis (OA). However, the mechanistic picture of this treatment is unclear. Existing pre-clinical studies have established the anti-inflammatory effects of LDRT at the cellular level, but a deeper understanding at the molecular level is needed. With this project, we aim to identify the anti-inflammatory molecular pathways triggered by LDRT.

This project is a physics-biology collaboration, leveraging physics expertise in microtomographic imaging (microCT) and small animal radiation research platform (SARRP), to investigate a novel model system. Uncovering the molecular targets that LDRT interact with will lay the foundation for future treatment technique optimization and dose response studies.